| Autor: |
Iwajomo OH; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom ; Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi., Finn A, Ogunniyi AD, Williams NA, Heyderman RS |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2013 Nov 04; Vol. 8 (11), pp. e78592. Date of Electronic Publication: 2013 Nov 04 (Print Publication: 2013). |
| DOI: |
10.1371/journal.pone.0078592 |
| Abstrakt: |
Pneumococcal disease is associated with a particularly high morbidity and mortality amongst adults in HIV endemic countries. Our previous findings implicating a B-cell defect in HIV-infected children from the same population led us to comprehensively characterize B-cell subsets in minimally symptomatic HIV-infected Malawian adults and investigate the isotype-switched IgG memory B-cell immune response to the pneumococcus. We show that similar to vertically acquired HIV-infected Malawian children, horizontally acquired HIV infection in these adults is associated with IgM memory B-cell (CD19(+) CD27(+) IgM(+) IgD(+)) depletion, B-cell activation and impairment of specific IgG B-cell memory to a range of pneumococcal proteins. Our data suggest that HIV infection affects both T-cell independent and T-cell dependent B-cell maturation, potentially leading to impairment of humoral responses to extracellular pathogens such as the pneumococcus, and thus leaving this population susceptible to invasive disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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