| Autor: |
Dygai AM; Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Scientific Future Management, Novosibirsk, Russia. ovpershina@gmail.com., Skurikhin EG, Ermakova NN, Reztsova AM, Pershina OV, Khmelevskaya ES, Krupin VA, Stepanova IE, Reztsova VM, Artamonov AV, Bekarev AA, Madonov PG, Kinsht DN |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Aug; Vol. 155 (4), pp. 501-6. |
| DOI: |
10.1007/s10517-013-2188-z |
| Abstrakt: |
Antifibrotic activity of testicular hyaluronidase, immobilized on polyethylenoxide and obtained by electron beam synthesis, was studied on the model of bleomycin injuries to the alveolar epithelium (irreversible pneumofibrosis) in C57Bl/6 mice and compared to the effect of testicular hyaluronidase. Intranasal therapy with immobilized and testicular hyaluronidases prevented the deposition of fibrotic mass in the parenchyma of "bleomycin" lungs. The effect of immobilized hyaluronidase was more pronounced than that of testicular hyaluronidase. The studied compounds were virtually inessential for infiltration of the alveolar interstitium and alveolar tracts by lymphocytes, macrophages, neutrophils, and plasma cells. Unchanged histoarchitectonics of bleomycin-damaged lungs in immobilized hyaluronidase therapy was due to suppression of the progenitor fibroblast cells (CD45(-)). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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