Effect of topical 0.05% cyclosporine A on corneal endothelium in patients with dry eye disease.
| Autor: | Pérez-Rico C; Department of Ophthalmology, University Hospital Principe de Asturias, University of Alcalá, Alcalá de Henares (Madrid), Spain., Germain F, Castro-Rebollo M, Moreno-Salgueiro A, Teus MÁ |
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| Jazyk: | angličtina |
| Zdroj: | International journal of ophthalmology [Int J Ophthalmol] 2013 Aug 18; Vol. 6 (4), pp. 471-4. Date of Electronic Publication: 2013 Aug 18 (Print Publication: 2013). |
| DOI: | 10.3980/j.issn.2222-3959.2013.04.12 |
| Abstrakt: | Aim: To determine the effect of topical 0.05% cyclosporine A (CsA) on corneal endothelium in patients with dry eye disease. Methods: Observational, prospective, case series study. Fifty-five eyes of 29 consecutive patients (9 males and 20 females; median age: 66.8 years, interquartile range: 61-73.2 years) with moderate-severe dry eye disease were evaluated. All patients were treated with topical 0.05% CsA ophthalmic emulsion twice a day in addition to lubricant eyedrops 5 times a day. The follow-up period was 12 months. Before treatment and at 3 and 12 months post-treatment central corneal specular microscopy was performed. The endothelial cell density (ECD), coefficient of variation of cell size (CoV), and percentage of hexagonal cells (Hex %) were analyzed. Results: The median ECDs pre-treatment and at 3 and 12 months post-treatment were 2 352.5/mm(2) (interquartile range, 2 178-2 548.5), 2364/mm(2) (interquartile range, 2 174.25-2 657.5), and 2366 cells/mm(2) (interquartile range, 2 174.75-2 539.75), respectively (P=0.927, one way ANOVA). The median CoVs pre-treatment and at 3 and 12 months post-treatment were 34.5 (interquartile range, 30-37), 35 (interquartile range, 30-38), and 34 (interquartile range, 30.75-38.25), respectively (P=0.7193, one way ANOVA). The median Hex % values pre-treatment and at 3 and 12 months post-treatment were 53 (interquartile range, 47-58), 54 (interquartile range, 45.75-59), and 50.5 (interquartile range, 45.75-58), respectively (P=0.824, one way ANOVA). Conclusion: Treatment of patients with dry eye disease for 12 months with topical 0.05% CsA does not seem to cause substantial changes on corneal endothelium. |
| Databáze: | MEDLINE |
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