Temporal associations for spatial events: the role of the dentate gyrus.

Autor: Morris AM; Department of Psychology, University of Utah, Salt Lake City, UT, USA., Curtis BJ, Churchwell JC, Maasberg DW, Kesner RP
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2013 Nov 01; Vol. 256, pp. 250-6. Date of Electronic Publication: 2013 Aug 22.
DOI: 10.1016/j.bbr.2013.08.021
Abstrakt: Previous research suggests that the dorsal dentate gyrus (DG) hippocampal subregion mediates spatial processing functions. However, a novel role for the DG in temporal processing for spatial information has begun to emerge based on the development of a computational model of neurogenesis. According to this model, adult born granule cells in the DG contribute to a temporal associative integration process for events presented closer in time. Currently, there is a paucity of behavioral evidence to support the temporal integration theory. Therefore, we developed a novel behavioral paradigm to investigate the role of the dDG in temporal integration for proximal and distal spatial events. Male Long-Evans rats were randomly assigned to a control group or to receive bilateral intracranial infusions of colchicine into the dDG. Following recovery from surgery, each rat was tested on a cued-recall of sequence paradigm. In this task, animals were allowed to explore identical objects placed in designated spatial locations on a cheeseboard maze across 2 days (e.g., Day 1: A and B; Day 2: C and D). One week later, animals were given a brief cue (A or C) followed by a preference test between spatial location B and D. Control animals had a significant preference for the spatial location previously paired with the cue (the temporal associate) whereas dDG lesioned animals failed to show a preference. These findings suggest that selective colchicine-induced dDG lesions are capable of disrupting the formation of temporal associations between spatial events presented close in time.
(Copyright © 2013 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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