| Autor: |
Hardtmann GE, Koletar G, Pfister OR, Gogerty JH, Iorio LC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1975 May; Vol. 18 (5), pp. 447-53. |
| DOI: |
10.1021/jm00239a001 |
| Abstrakt: |
On treatment of N-substituted isatoic anhydrides with 2-methylmercaptoimidazolines, 10-substituted imidazo[2,1-b]quinazolin-5(10H)-ones are obtained. Several members of this class exhibited pronounced broncholytic activity. The structure-activity relationships (based on results obtained in the guinea pig histamine aerosol test) of these nonsympathomimetic bronchodilators are discussed. In addition, the detailed pharmacological evaluation of two analogs found to be five to ten times more active than theophyline as bronchodilators without having central nervous system or cardiovascular side effects is described. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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