Presymptomatic prediction of preeclampsia with angiogenic factors, in high risk pregnant women.

Autor: Teixeira PG; Fetal Medicine Center, Obstetrics and Gynecology Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. patigt@terra.com.br, Reis ZS, Andrade SP, Rezende CA, Lage EM, Velloso EP, Santana CA, Cabral AC
Jazyk: angličtina
Zdroj: Hypertension in pregnancy [Hypertens Pregnancy] 2013 Aug; Vol. 32 (3), pp. 312-20.
DOI: 10.3109/10641955.2013.807818
Abstrakt: Introduction: The aim of this study was to investigate the value of placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PLGF ratio, in predicting symptomatic preeclampsia (PE).
Methods: A prospective longitudinal study was carried out on 71 high risk preeclamptic women cohort. All of them had normal blood pressure level (≤140/90 mmHg) at the time of enrolment, 26.8 ± 1.5 weeks. Maternal blood was collected and plasma was stored in a freezer at -80 °C. PE was defined according to the National High Blood Pressure Education Program Working Group Criteria. Accuracy of angiogenic factors in predicting PE was evaluated using Receiver-operating characteristics.
Results: Maternal plasma concentrations of PLGF and sFlt-1 were able to predict PE (0.90, p < 001; 0.78, p = 0.003, area under the curve, respectively) but the sFlt-1/PLGF ratio presented the best prediction potential over the others (0.95, area under the curve, p < 0.001).
Conclusion: All angiogenesis factors were effective biomarkers in predicting PE during the second trimester, before the clinical onset of PE.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje