Filgrastim therapy in a child with neutropenia induced by linezolid.

Autor: Hernández Segurado M; Pharmacy Service, Fundación Jiménez Díaz University Hospital, Avenue Reyes Católicos, 2, 28040, Madrid, Spain. mhernandezs@fjd.es, Arias Moya MÁ, Gómez Pérez M, Bonilla Porras M, Castillo Bazán E, Bécares Martínez FJ, Toledano Mayoral G, Panadero Esteban MI
Jazyk: angličtina
Zdroj: International journal of clinical pharmacy [Int J Clin Pharm] 2013 Aug; Vol. 35 (4), pp. 538-41. Date of Electronic Publication: 2013 Jul 03.
DOI: 10.1007/s11096-013-9814-8
Abstrakt: We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient's neutrophil-count. However, more experience with the off-label use of filgrastrim is needed in the pediatric population.
Databáze: MEDLINE