| Autor: |
Zdrazilova-Dubska L; Department of Laboratory Medicine, Masaryk Memorial Cancer Institute, Brno, Czech Republic. dubska@mou.cz, Valik D, Budinska E, Frgala T, Bacikova L, Demlova R |
| Jazyk: |
angličtina |
| Zdroj: |
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti [Klin Onkol] 2012; Vol. 25 Suppl 2, pp. 2S21-5. |
| Abstrakt: |
CD3+ CD56+ NKT-like cells have been shown to produce substantial amounts of pro-inflammatory cytokines and to mediate lysis of malignant cells. Using flow cytometry, we evaluated the absolute NKT-like cell count in peripheral blood from individuals in a reference population and the median number was 0.085 x 10(9)/l. The average number of NKT-like cells in patients with disseminated cancer was 2.65 fold higher than in the reference population. The number of CD3+ CD56+ cells in solid tumour patients who achieved complete remission was comparable to the reference population. In breast cancer patients with initially (prior to therapy) increased number of NKT-like cells, we observed a trend toward longer disease-free survival. Thus we conclude that CD3+ CD56+ NKT-like cells have potential to suppress tumour evasion and are expanded in peripheral blood of some epithelial tumour patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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