| Autor: |
Pfeiffer B; ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences HCI H405, Wolfgang-Pauli-Str. 10, CH-8093, Zürich, Switzerland., Kuzniewski CN, Wullschleger C, Altmann KH |
| Jazyk: |
angličtina |
| Zdroj: |
Topics in current chemistry [Top Curr Chem] 2009; Vol. 286, pp. 1-72. |
| DOI: |
10.1007/128_2008_9 |
| Abstrakt: |
This article provides an overview on the chemistry and structure-activity relationships of macrolide-based microtubule-stabilizing agents. The primary focus will be on the total synthesis or examples thereof, but a brief summary of the current state of knowledge on the structure-activity relationships of epothilones, laulimalide, dictyostatin, and peloruside A will also be given. This macrolide class of compounds, over the last decade, has become the subject of growing interest due to their ability to inhibit human cancer cell proliferation through a taxol-like mechanism of action. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
