Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice.

Autor: Marques FS; Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão 121, Candeal, Salvador, BA, Brazil., Silva JS, Couto RD, Barreto EP Jr, Ribeiro-dos-Santos R, dos Santos WL, Soares MB
Jazyk: angličtina
Zdroj: Renal failure [Ren Fail] 2013; Vol. 35 (5), pp. 776-81. Date of Electronic Publication: 2013 Apr 08.
DOI: 10.3109/0886022X.2013.780660
Abstrakt: Objective: Recent studies have demonstrated the therapeutic effects of bone marrow-derived cells in tissue regeneration. The aim of this study was to investigate the effects of bone marrow mononuclear cell (BMMC) transplantation in a mouse model of acute renal failure (ARF) induced by mercuric chloride.
Methods: BMMC was isolated from male BALB/c mice and injected into female mice treated with a lethal dose (LD90) of mercuric chloride. Survival rate, histopathological analysis, and assessment of urea, creatinine, sodium, potassium, and mercury levels were carried out.
Results: Cellular therapy with BMMC significantly reduced the mortality induced by mercuric chloride (p < 0.05). This finding correlated with a decrease in serum levels of urea (p = 0.04) and potassium (p < 0.01). However, no differences in renal morphology were observed when BMMC-treated and control group were compared.
Conclusion: Transplanted BMMC improve renal function and reduce mortality and, therefore, may represent a new therapeutic alternative to treat ARF.
Databáze: MEDLINE
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