| Autor: |
Labuda LA; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Ateba-Ngoa U, Feugap EN, Heeringa JJ, van der Vlugt LE, Pires RB, Mewono L, Kremsner PG, van Zelm MC, Adegnika AA, Yazdanbakhsh M, Smits HH |
| Jazyk: |
angličtina |
| Zdroj: |
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2013; Vol. 7 (3), pp. e2094. Date of Electronic Publication: 2013 Mar 07. |
| DOI: |
10.1371/journal.pntd.0002094 |
| Abstrakt: |
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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