| Autor: |
Lamb LM; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA., Crandon JL, Nicolau DP |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Apr; Vol. 57 (4), pp. 1971-3. Date of Electronic Publication: 2013 Jan 28. |
| DOI: |
10.1128/AAC.02170-12 |
| Abstrakt: |
P-873 is a novel compound in the RX-04 pyrrolocytosine series of protein synthesis inhibitors currently under development by Rib-X Pharmaceuticals. We evaluated the pharmacodynamic and pharmacokinetic properties of this compound against Klebsiella pneumoniae using a murine neutropenic thigh infection model. P-873 demonstrated potent and rapid in vivo activity against this organism with enhanced penetration and duration of exposure in thigh tissue. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
