Response to the complete hepatitis B vaccine regimen in infants under 12 months of age: a case series.
| Autor: | Miralha AL; Universidade do Estado do Amazonas, Amazonas Foundation of Tropical Medicine, Manaus, AM, Brazil. alexmiralha@hotmail.com, Malheiro A, Miranda AE, Rutherford GW, Alecrim Md |
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| Jazyk: | angličtina |
| Zdroj: | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2013 Jan-Feb; Vol. 17 (1), pp. 82-5. Date of Electronic Publication: 2012 Dec 29. |
| DOI: | 10.1016/j.bjid.2012.07.019 |
| Abstrakt: | Objectives: Describing rates of seroconversion and its associated factors in a series of Brazilian infants following the final dose of the vaccine at 6 months of age. Methods: Peripheral blood samples were collected after the third dose of the vaccine for the detection of anti-hepatitis B surface antibodies among infants of 7-12 months of age. We measured the association between seroconversion and birthweight, gestational age, time since administration of the vaccine in the maternity hospital and whether or not testing for hepatitis B surface antigen had been performed during pregnancy. Results: We examined 40 infants. The mean birthweight was 2787g (standard deviation=853g) and mean gestational age was 37.5 (standard deviation=3.08) weeks. The proportion that seroconverted was non-significantly higher in infants who weighed ≥2000g at birth (96.7%) than in those with birthweights <2000g (80%, p=0.149). There was no difference between the infants who were born at <37 weeks of gestational age and those born at ≥37 weeks (p<0.178) neither between seroconversion and the time of application of the first dose of the vaccine after delivery (p=0.202). Conclusion: The proportion of infants who seroconverted was similar to that found in other Brazilian studies. There were no differences in the proportion seroconverting by age at first immunization. (Copyright © 2013 Elsevier Editora Ltda. All rights reserved.) |
| Databáze: | MEDLINE |
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