Risk factors for recurrence of clostridium difficile-associated diarrhoea.
| Autor: | Samie AA, Traub M, Bachmann K, Kopischke K, Theilmann L |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Hepato-gastroenterology [Hepatogastroenterology] 2013 Sep; Vol. 60 (126), pp. 1351-4. |
| DOI: | 10.5754/hge12588 |
| Abstrakt: | Background/aims: Clostridium difficile associated disease (CDAD) is one of the most common causes of hospital-acquired diarrhea. Despite increasing incidence of clostridium difficile-associated diarrhea, there are few data on risk factors associated with its relapse. Methodology: We studied retrospectively possible risk factors for the recurrence of CDAD; 124 patients fulfilled the criteria of CDAD during the study period between January 2006 and July 2009. After successful treatment, recurrence occurred in 20 patients. Results: Nineteen patients (95%, p = 0.029) in the relapse group were on long term proton pump inhibitor therapy compared to 77 patients (74%) in the non-relapse group. There was no statistically significant difference in severity (CRP: p = 0.442, leucocytosis: p = 0.415) and length of hospitalization (p= 0.539) in both studied groups; however, CDAD-relapse was associated with more hospital readmissions and increased health care costs. Conclusions: Proton pump inhibitor therapy may be associated with increased risk of recurrence of CDAD, and represents a relevant, yet correctable risk factor. In patients at risk for CDAD, proton pump inhibitors should be used carefully. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|