[Synthesis and anti-tumor properties of myelopeptide MP-1].

Autor: Fonina LA, Treshchalina EM, Belevskaia RG, Az'muko AA, Efremov MA, Sedakova LA, Kirilina EA
Jazyk: ruština
Zdroj: Bioorganicheskaia khimiia [Bioorg Khim] 2012 Jul-Aug; Vol. 38 (4), pp. 406-12.
DOI: 10.1134/s1068162012040073
Abstrakt: We have studied anti-tumor properties of bone marrow derived peptide Phe-Leu-Gly-Phe-Pro-Thr (MP-1) synthesized by classical methods. It was shown that MP-1 enhanced the effect ofcytostatic therapy of lymphatic leukemia P388 and increased latent growth period of P388 tumors implanted in irradiated mice. MP-1 also decreased metastasis of mouse breast adenocarcinoma Ca-755 after surgery.
Databáze: MEDLINE