| Autor: |
Bertini I; CERM University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy. ivanobertini@cerm.unifi.it, Felli IC, Gonnelli L, Vasantha Kumar MV, Pierattelli R |
| Jazyk: |
angličtina |
| Zdroj: |
Chembiochem : a European journal of chemical biology [Chembiochem] 2011 Oct 17; Vol. 12 (15), pp. 2347-52. |
| DOI: |
10.1002/cbic.201100406 |
| Abstrakt: |
Order in disorder: The characterization of intrinsically disordered proteins by NMR spectroscopy is a necessity on the one hand and a continuous challenge on the other. We propose two experiments that provide diagnostic parameters to monitor the degree of unfolding of a polypeptide. The test was performed on the yeast Cox17 protein, known to gain its function through maturation from an intrinsically disordered state (see figure). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text