| Autor: |
Sikorska J; Department of Pharmaceutical Sciences, College of Pharmacy, 203 Pharmacy Building, Oregon State University, Corvallis, Oregon 97331, USA., Parker-Nance S, Davies-Coleman MT, Vining OB, Sikora AE, McPhail KL |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2012 Oct 26; Vol. 75 (10), pp. 1824-7. Date of Electronic Publication: 2012 Oct 02. |
| DOI: |
10.1021/np300580z |
| Abstrakt: |
The CH₂Cl₂-MeOH extract of a South African tunicate described as the new Synoicum globosum Parker-Nance sp. nov. (Ascidiacea, Aplousobranchia) was subjected to ¹H NMR-guided fractionation. This resulted in the identification of new 3″-bromorubrolide F (1), 3'-bromorubrolide E (2), 3'-bromorubrolide F (3), and 3',3″-dibromorubrolide E (4) and reisolation of known rubrolides E (5) and F (6), based on NMR spectroscopic and mass spectrometric data. Biological testing of both new and known members of this reported antimicrobial family of halogenated, aryl-substituted furanones indicated moderate antibacterial properties for 3'-bromorubrolide E (2), 3',3″-dibromorubrolide E (4), and rubrolide F (6) against methicillin-resistant Staphylococcus aureus (MRSA) and S. epidermidis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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