Intraoperative hepatic artery blood flow predicts early hepatic artery thrombosis after liver transplantation.

Autor: Marín-Gómez LM; Liver Transplant Unit, University Hospital Virgen Del Rocío, Seville, Spain. luism.marin.sspa@juntadeandalucia.es, Bernal-Bellido C, Alamo-Martínez JM, Porras-López FM, Suárez-Artacho G, Serrano-Diaz-Canedo J, Padillo-Ruiz J, Gómez-Bravo MA
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2012 Sep; Vol. 44 (7), pp. 2078-81.
DOI: 10.1016/j.transproceed.2012.07.077
Abstrakt: Hepatic artery complications after orthotopic liver transplantation are associated with a high rate of graft loss and mortality (23% to 35%) because they can lead to liver ischemia. The reported incidence of hepatic artery thrombosis (HAT) after adult liver transplantation is 2.5% to 6.8%. Typically, these patients are treated with urgent surgical revascularization or emergent liver retransplantation. Since January 2007, we have recorded the postanastomotic hepatic artery flow after revascularization. The aim of this study was to assess the relationship between hepatic blood flow on revascularization and early HAT. Retrospectively, we reviewed perioperative variables from 110 consecutive liver transplantation performed at the Virgen del Rocío University Hospital (Seville, Spain) between January 2007 and October 2010. We evaluated the following preoperative (donor and recipient) and intraoperative variables: donor and recipient age, cytomegalovirus serology, ABO-compatibility, anatomical variations of the donor hepatic artery, number of arterial anastomoses, portal and hepatic artery flow before closure, cold ischemia time, and blood transfusion. These variables were included in a univariate analysis. Of the 110 patients included in the study, 85 (77.7%) were male. The median age was 52 years. ABO blood groups were identical between donor and recipient in all the patients. The prevalence of early HAT was 6.36% (7 of 110). Crude mortality with/without HAT was 22% versus 2% (P = .001), respectively. Crude graft loss rate with/without HAT was 27% versus 4% (P = .003), respectively. Early HAT was shown to be primarily associated with intraoperative hepatic artery blood flow (93.3 mL/min recipients with HAT versus 187.7 mL/min recipients without HAT, P < .0001). No retransplantation showed early HAT. In our experience, intraoperative hepatic artery blood flow predicts early HAT after liver transplantation.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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