| Autor: |
Blinov DS; Medical Institute of N. P. Ogarev Mordovian State University, Saransk, Russia. blinovpharm@yandex.ru, Sernov LN, Balashov VP, Blinova EV, Pivkina LV, Gogina ED, Van'kova LV, Vertyankin MV, Boiko GG, Krasilina TV |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Mar; Vol. 152 (5), pp. 583-6. |
| DOI: |
10.1007/s10517-012-1581-3 |
| Abstrakt: |
Experiments on rats with myocardium infarction showed that intravenous administration of etoxidol in a dose of 14.2 mg/kg restricted the size of necrosis area and reduced the ratio of necrosis/ischemia zones. The test compound reduced the risk of rhythm and conduction disturbances induced by administration of toxic epinephrine doses to the mice, and increased mouse survival. Etoxidol administered intravenously to cats with acute myocardial ischemia reduced epinephrine concentration and intensity of free radical oxidation in zones of myocardial lesions against the background of the increase in norepinephrine concentration and antioxidant activity in the myocardium. By antiischemic and antioxidant activity, etoxidol was superior to its structural analogue mexidol. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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