Expansion of follicular helper T cells in the absence of Treg cells: implications for loss of B-cell anergy.

Autor: Leonardo SM; Division of Allergy/Immunology, Department of Pediatrics, Medical College of Wisconsin, The Children's Research Institute, Milwaukee, WI 53226, USA., De Santis JL, Gehrand A, Malherbe LP, Gauld SB
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2012 Oct; Vol. 42 (10), pp. 2597-607. Date of Electronic Publication: 2012 Aug 06.
DOI: 10.1002/eji.201242616
Abstrakt: The maintenance of B-cell anergy is essential to prevent the production of autoantibodies and autoimmunity. However, B-cell extrinsic mechanisms that regulate B-cell anergy remain poorly understood. We previously demonstrated that regulatory T (Treg) cells are necessary for the maintenance of B-cell anergy. We now show that in Treg-cell-deficient mice, helper T cells are necessary and sufficient for loss of B-cell tolerance/anergy. In addition, we show that the absence of Treg cells is associated with an increase in the proportion of CD4(+) cells that express GL7 and correlated with an increase in germinal center follicular helper T (GC-T(FH) ) cells. These GC-T(FH) cells, but not those from Treg-cell-sufficient hosts, were sufficient to drive antibody production by anergic B cells. We propose that a function of Treg cells is to prevent the expansion of T(FH) cells, especially GC-T(FH) cells, which support autoantibody production.
(© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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