| Autor: |
Churina EG, Urazova OI, Novitskiĭ VV, Kolosova AE, Sionina EV, Filiniuk OV, Voronkova OV, Naslednikova IO |
| Jazyk: |
ruština |
| Zdroj: |
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2012 Apr (4), pp. 26-9. |
| Abstrakt: |
The article deals with the characteristics of sup-population composition of T-regulator: cells with suppressor activity and production of immunoregulatory cytokines suppressing immune response (IL-10, TGF-beta) in patients with infiltrative tuberculosis of lungs. It is proved that the leading role in formation of immunodepression and tuberculin anergy under infiltrative tuberculosis of lungs is played by T-regulatory, cells with phenotype CD4+CD25+Foxp3+. It is demonstrated that the immunodepression mediated by cytokine production is connected with increasing of both basal and BCG-induced secretion of IL-10 on the background of decrease of level of production of TGF-beta by mononuclear leukocytes in vitro. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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