[Characteristic of microglial activation of hippocampus in experimental epileptic rats].

Autor:	Sun H; Department of Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, China. sunhongxjt@yahoo.cn, Wu HQ, Zhang GL, Zhan SQ, Zhang R, Wang HQ
Jazyk:	čínština
Zdroj:	Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2012 May; Vol. 41 (3), pp. 310-4.
DOI:	10.3785/j.issn.1008-9292.2012.03.013
Abstrakt:	Objective: To investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats. Methods: Morphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats. Results: OX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d. Conclusion: Inflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.
Databáze:	MEDLINE
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