| Autor: |
Kim Y; David H. Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, United States., Lee Chung B, Ma M, Mulder WJ, Fayad ZA, Farokhzad OC, Langer R |
| Jazyk: |
angličtina |
| Zdroj: |
Nano letters [Nano Lett] 2012 Jul 11; Vol. 12 (7), pp. 3587-91. Date of Electronic Publication: 2012 Jun 20. |
| DOI: |
10.1021/nl301253v |
| Abstrakt: |
Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process but are restricted by a low throughput. In this study, we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e., Reynolds number (30-150)) we can control the nanoparticle size (30-170 nm) with high productivity (∼3 g/hour) and low polydispersity (∼0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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