Evaluation of bone marrow aspirates from multiple sites for staging of canine lymphoma and mast cell tumours.

Autor: Aubry OA; Department of Clinical Sciences, Auburn University, Auburn, AL, USA; Southern California Veterinary Specialty Hospital, Irvine, CA, USA., Spangler EA, Schleis SE, Smith AN
Jazyk: angličtina
Zdroj: Veterinary and comparative oncology [Vet Comp Oncol] 2014 Mar; Vol. 12 (1), pp. 58-66. Date of Electronic Publication: 2012 May 11.
DOI: 10.1111/j.1476-5829.2012.00331.x
Abstrakt: This prospective study evaluated the utility of bone marrow aspirates (BMAs) obtained from multiple sites for staging of canine lymphoma (LSA) and mast cell tumours (MCTs). Forty dogs (LSA, n = 24; MCTs, n = 16) were enrolled, but only 33 (82.5%) had diagnostic bone marrow (BM) aspirates obtained from two sites for inclusion in the study. Nineteen dogs with LSA were included, and 6 (31.6%) had BM involvement. Neoplastic lymphocytes were present in BM from both sites in all of these dogs. Fourteen dogs with MCTs were included, and 3 (21.4%) had BM involvement. Neoplastic mast cells were present at both sites in two dogs and at only one site in the third. These results indicate that BMAs from multiple sites may not be needed for accurate staging of canine LSA patients, but more studies evaluating the pattern of BM infiltration in dogs with high-grade MCTs are warranted.
(© 2012 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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