The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men.

Autor: Unni US; Division of Nutrition, St John's Research Institute, St John's National Academy of Health Sciences, Bangalore 560034, India. uma@sjri.res.in, Raj T, Sambashivaiah S, Kuriyan R, Uthappa S, Vaz M, Regan MM, Kurpad AV
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2012 Dec; Vol. 31 (6), pp. 903-10. Date of Electronic Publication: 2012 Apr 22.
DOI: 10.1016/j.clnu.2012.03.008
Abstrakt: Background & Aims: The 2007 FAO/WHO/UNU lysine requirement is 30 mgkg(-1)d(-1). Developing country populations may be at risk of lysine deficiency, with effects on muscle and its function. The effect of an 8 wk lysine supplementation diet on muscle mass and function was assessed.
Methods: Healthy, under and well-nourished men were studied before and after 8 wk, during which low (n=20) and high (n=20) lysine diets were consumed. The low lysine diets (∼25 and ∼40 mgkg(-1)d(-1) for under and well-nourished respectively) were based on the subjects' habitual lysine intake, while the high lysine diet supplied 80 mgkg(-1)d(-1). Anthropometry, muscle function, insulin sensitivity (IS) and leucine kinetics were measured before and after the experimental period.
Results: The high lysine diet had a small positive effect (about +7.5%) on muscle strength, but no effect on other parameters. Over the 8 wk period in the whole group, the change in muscle strength correlated with the change in muscle mass (r=0.5, P=0.001), while the change in muscle mass correlated with the change in IS (r=0.3, P=0.04), but there were no intake specific differences.
Conclusion: Over an 8 wk controlled feeding period, an intake of 80 mg lysine kg(-1)d(-1) had a small positive effect on muscle strength, but no other effects.
(Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
Databáze: MEDLINE
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