Comparative study of the expression of ATF-3 and ATF-4 genes in vessels involved into atherosclerosis process and in psoriatic skin.

Autor: Sobolev VV; N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. sobolev_vl@mail.ru, Starodubtseva NL, Piruzyan AL, Minnibaev MT, Sautin ME, Tumanov VP, Bruskin SA
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2011 Oct; Vol. 151 (6), pp. 713-6.
DOI: 10.1007/s10517-011-1423-8
Abstrakt: Expression of ATF-3 and ATF-4 genes was examined quantitatively by real-time PCR and changes in the expression of these genes in atherosclerotic lesions and in psoriatic skin were demonstrated. It was found that concomitant pathologies do not affect the expression of these genes. Opposite changes in the expression of ATF-3 and ATF-4 genes in atherosclerotic and psoriatic samples were revealed and a hypothesis was put forward that this parameter could be a criterion of pathological process in both diseases.
Databáze: MEDLINE