A review of troponins in ischemic heart disease and other conditions.

Autor: Skeik N; Assistant Professor, University of Southern Maine, Maine, Medical Instructor, Dartmouth Medical School, New Hampshire, Internist, St Mary's Regional Medical Center, Lewiston, Maine., Patel DC
Jazyk: angličtina
Zdroj: The International journal of angiology : official publication of the International College of Angiology, Inc [Int J Angiol] 2007 Summer; Vol. 16 (2), pp. 53-8.
DOI: 10.1055/s-0031-1278248
Abstrakt: Measuring cardiac troponin (cTn) I and T levels is currently considered to be a cornerstone for making the diagnosis of acute coronary syndrome (ACS).Based on current literature, cTnI and cTnT are known to be very sensitive and specific for myocardial damage, regardless of the underlying cause. Lately, it has been found that cTns can be elevated and reflect worse prognoses in many situations where ACS is excluded. Such information can affect the validity of cTns as markers for ACS without classic symptoms. This may call for a revision of the troponin cutoff values to make a diagnosis of ACS. Furthermore, it opens a new field of study to determine appropriate management of patients with elevated cTn levels in whom ACS has been excluded.
Databáze: MEDLINE