| Autor: |
Zheng S; Institute of Pesticide Science, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, China., Laraia L, O' Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2012 Apr 07; Vol. 10 (13), pp. 2590-3. Date of Electronic Publication: 2012 Feb 23. |
| DOI: |
10.1039/c2ob25065a |
| Abstrakt: |
A novel synthesis of the ellagitannin natural product tellimagrandin I and a series of medium ring analogues is described. These compounds were all subsequently screened for redox activity, ability to precipitate protein and cellular phenotype in HeLa cells. From this we have shown that all properties can be modulated independently by varying ring size and by moving the ester out of conjugation with the biaryl ring system. Increasing ring size increased redox activity and cytotoxicity, leading to the identification of a compound (10) which was significantly more cytotoxic. In addition compounds identified with a redox active scaffold and low cytotoxicity may be employed as a new class of redox probes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
