| Autor: |
Nascimento MV; Laboratory of Pharmacology of Natural Products, Institute of Biological Sciences, Federal University of Goias, Goiânia, Brazil. xico@icb.ufg.br, Galdino PM, Florentino IF, de Brito AF, Vanderlinde FA, de Paula JR, Silva Rdo N, Costa EA |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2012; Vol. 26 (23), pp. 2274-9. Date of Electronic Publication: 2012 Jan 31. |
| DOI: |
10.1080/14786419.2011.653973 |
| Abstrakt: |
Spiranthera odoratissima A. St.-Hil., 'manacá', is a medicinal species used in Brazil, especially in central region, for the treatment of several diseases such as pain and inflammation. In this study, the methanol/aqueous phase of the ethanol extract of the leaves of 'manacá' (MAP), at the doses of 50, 150 and 500 mg/kg was used to evaluate the anti-inflammatory and/or antinociceptive effects and the possible anti-inflammatory mechanism. The antinociceptive and anti-inflammatory activities of MAP were assessed using formalin test, carrageenan-induced paw oedema. The myeloperoxidase activity, capillary permeability, leukocyte migration and tumour necrosis factor alpha (TNF-α) levels were evaluated in pleural exudate. The MAP reduced the licking time only in the later phase of formalin test, and showed anti-inflammatory activity by reducing the paw oedema, migration cell, myeloperoxidase activity, capillary permeability and TNF-α levels. In conclusion, we confirmed the inflammatory activity of MAP and affirm that this effect involves the reduction of TNF-α level. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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