| Autor: |
Rickinson AB, Moss DJ, Pope JH |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of cancer [Int J Cancer] 1979 May 15; Vol. 23 (5), pp. 610-7. |
| DOI: |
10.1002/ijc.2910230505 |
| Abstrakt: |
Regression of EB-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus-infected T-cell-depleted population in order to establish regression in the culture. The in vitro regression phenomenon was strongly T-cell-dependent but did not require the presence of either monocytes or, as a potential antigenic stimulus, the residual viral envelope material on the surface of virus-infected B cells. The T-cell-depleted population from seropositive donors sometimes transformed (7/60 cultures) without the experimental addition of virus. Regression appeared to be independent of cytotoxic mechanisms involving anti-viral antibodies and not to be mediated by soluble factors released into culture medium. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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