| Autor: |
Lokshin A, Polianskaia NI, Mashkovtsev IuV, Merkulova IV, Sokolova VK, Gavrilova TN |
| Jazyk: |
ruština |
| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1990 Jul; Vol. 110 (7), pp. 88-9. |
| Abstrakt: |
BRO human melanoma cells encapsulated within a fibrin clot grew rapidly in mice immunosuppressed (IS) by wholebody irradiation (5.5 or 6.5 Gy). After 8 days growth under the sub-renal capsule (SRC) of IS mice, the tumor volume increased 40-fold on the average, and histological and cytological examination showed that the growth consisted almost entirely of viable tumor cells. Marked tumor growth in IS mice also was observed after intraperitoneal implantation of fibrin clots containing BRO cells. SRC implantation of encapsulated BRO cells in pre-irradiated mice offers a practical and reproducible method for evaluating the growth of human tumors in vivo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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