| Autor: |
Giardina WJ; Department of General Pharmacology, Abbott Laboratories, Abbott Park, IL., Kleinert HD, Ebert DM, Wismer CT, Chekal MA, Stein HH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of ocular pharmacology [J Ocul Pharmacol] 1990 Summer; Vol. 6 (2), pp. 75-83. |
| DOI: |
10.1089/jop.1990.6.75 |
| Abstrakt: |
Corneal application of enalkiren (ABBOTT-64662), [N-(3-amino-3-methyl-1- oxobutyl)-4-methoxy-L-phenylalanyl]-N-[1S,2R,3S)-1-(cyclohexylmethyl+ ++)-2,3- dihydroxy-5-methylhexyl]-L-histidinamide], a renin inhibitor compound, lowered intraocular pressure (IOP) in unanesthetized rabbits and anesthetized monkeys. IOP was significantly decreased for at least 60 minutes after administration of a 0.3% solution of enalkiren in monkeys and for at least 90 minutes after the administration of 0.1% and 0.3% solutions in rabbits. Enalkiren did not affect systemic blood pressure or heart rate in anesthetized monkeys after topical application to the cornea. The IOP lowering activity of enalkiren suggests a potential functional role for the renin angiotensin system in the modulation of IOP. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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