Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.

Autor: Molina DP; Department of Neurobiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2012 Sep; Vol. 33 (9), pp. 1938-49. Date of Electronic Publication: 2011 Oct 19.
DOI: 10.1016/j.neurobiolaging.2011.09.014
Abstrakt: Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) have been documented in aged animals and may contribute to changes in hippocampal-dependent memory. Growth hormone (GH) regulates AMPA-R and NMDA-R-dependent excitatory transmission and decreases with age. Chronic GH treatment mitigates age-related cognitive decline. An in vitro CA1 hippocampal slice preparation was used to compare hippocampal excitatory transmission and plasticity in old animals treated for 6-8 months with either saline or GH. Our findings indicate that GH treatment restores NMDA-R-dependent basal synaptic transmission in old rats to young adult levels and enhances both AMPA-R-dependent basal synaptic transmission and long-term potentiation. These alterations in synaptic function occurred in the absence of changes in presynaptic function, as measured by paired-pulse ratios, the total protein levels of AMPA-R and NMDA-R subunits or in plasma or hippocampal levels of insulin-like growth factor-I. These data suggest a direct role for GH in altering age-related changes in excitatory transmission and provide a possible cellular mechanism through which GH changes the course of cognitive decline.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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