Insights into Acinetobacter baumannii pathogenicity.

Autor: Cerqueira GM; Faculty of Medicine, Nursing and Health Sciences, Department of Microbiology, Monash University, Melbourne, Australia., Peleg AY
Jazyk: angličtina
Zdroj: IUBMB life [IUBMB Life] 2011 Dec; Vol. 63 (12), pp. 1055-60. Date of Electronic Publication: 2011 Oct 12.
DOI: 10.1002/iub.533
Abstrakt: Acinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a "red-alert" human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abilities to survive in a diverse range of environments, including those within healthcare institutions, leading to problematic outbreaks. Historically, the virulence of the organism has been questioned, but recent clinical reports suggest that Acinetobacter can cause serious, life-threatening infections. Furthermore, its metabolic adaptability gives it a selective advantage in harsh hospital environments. This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism.
(Copyright © 2011 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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