| Autor: |
Gaponova NI, Abdrakhmanov VR, Baratashvili VL, Tereshchenko SN |
| Jazyk: |
ruština |
| Zdroj: |
Kardiologiia [Kardiologiia] 2011; Vol. 51 (6), pp. 91-6. |
| Abstrakt: |
In the review we present detailed analysis of antihypertensive action of 3-nd generation sympatholytic moxonidine. Due to selective interaction with imidazoline I1-receptors moxonidine diminishes sympathetic activity causing lowering of peripheral vascular resistance. This leads to significant lowering of systolic and diastolic arterial pressure. Efficacy and safety of the drug has been shown both for the management of uncomplicated hypertensive crises and long term treatment of arterial hypertension (AH). Appropriateness of the use of moxonidine in patients with AH combined with diabetes mellitus, metabolic syndrome, chronic obstructive pulmonary disease has been confirmed. Moxonidine is well tolerated; its bioavailability after oral intake reaches 90%. The drug produces neither hypotensive "first dose" nor rebound effects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
