Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17.

Autor: Dungan LS; School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland., Mills KH
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2011 Oct; Vol. 56 (1), pp. 126-32. Date of Electronic Publication: 2011 Aug 06.
DOI: 10.1016/j.cyto.2011.07.007
Abstrakt: The interleukin (IL)-1 cyokine family plays a vital role in inflammatory responses during infection and in autoimmune diseases. The pro-inflammatory cytokines, IL-1β and IL-18 are members of the IL-1 family that require cleavage by caspase-1 in the inflammasome to generate the mature active cytokines. Cells of the innate immune system, including γδ T cells and invariant natural killer T (iNKT) cells respond rapidly to invading pathogens by producing inflammatory cytokines, such as IFN-γ and IL-17. IL-1β or IL-18 in combination with IL-23 can induce IL-17 production by γδ T cells without T cell receptor (TCR) engagement. IL-1β and IL-23 can also synergize to induce IL-17 production by iNKT cells. Furthermore, CD4+ αβ effector memory T cells secrete IL-17 in response to IL-23 in combination with either IL-1β or IL-18, in the absence of any TCR stimulation. The early IL-17 produced by innate cells induces recruitment of neutrophils to the site of infection, stimulates local epithelial cells to secrete anti-microbial proteins, such as lipocalins and calgranulins, induces production of structural proteins important in tight junction stability, and promotes production of matrix metalloproteinases. Caspase-1 processed IL-1 family cytokines therefore play a vital role in the innate immune response and induction of IL-17 from innate immune cells which functions to fight infections and promote autoimmunity.
(Copyright © 2011 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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