| Autor: |
Drozd NN, Miftakhova NT, Savchik EIu, Kalinina TB, Makarov VA, Imbs TI, Zviagintseva TN, Kuznetsova TA, Besednova NN |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2011; Vol. 74 (5), pp. 26-30. |
| Abstrakt: |
The antithrombotic and hemorrhagic activities of fucoidan with molecular weight within 20 - 40 kD isolation from Fucus evanescens seaweed have been investigated. The antithrombin activity of fucoidan is 41 +/- 9 aIIa IU/mg and the anti-factor Oà activity is 38 +/- 8 aOà IU/mg. The antithrombin and anti-factor Oà activities of plasma, antithrombotic activity (100% prevention of formation of a blood clot observed at a dose of 10 mg/kg), and hemorrhagic activity (to a lesser degree, than that of unfractionated heparin in comparable antithrombotic activity doses) increase as the doses of fucoidan increases from 2.5 to 10 mg/kg at intravenous injection in rats. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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