| Abstrakt: |
The paper presents data on age-related cytokine dysregulation in children with tertian or tropical malaria infection. Immunological changes depended on the dynamics of the infectious process and the severity of the pathological one. The most pronounced changes were observed in a group of infants probably due to the functional immaturity of immunoregulatory mechanisms appearing as elevated levels of proinflammatory cytokines with a reduction in IFN-gamma, which suggest that Th-1 lymphocyte reactions are inhibited. With age, there is a shift from Th2 towards Th1 immune response, which testifies that the disease runs a favorable course. These findings may be useful in assessing the prognosis of the course and outcome of malaria in children. |
