Randomized study of minocycline and edetic acid as a locking solution for central line (port-a-cath) in children with cancer.
| Autor: | Ferreira Chacon JM; Department of Pediatric Oncology, Hospital Darcy Vargas, São Paulo, Brazil., Hato de Almeida E, de Lourdes Simões R, Lazzarin C Ozório V, Alves BC, Mello de Andréa ML, Santiago Biernat M, Biernat JC |
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| Jazyk: | angličtina |
| Zdroj: | Chemotherapy [Chemotherapy] 2011; Vol. 57 (4), pp. 285-91. Date of Electronic Publication: 2011 Jul 21. |
| DOI: | 10.1159/000328976 |
| Abstrakt: | Background: Contamination of central catheters is frequent, and biofilm perpetuates infections. Heparin does not protect against infections because it has no antibiotic action. Minocycline and edetic acid (M-EDTA), a potent calcium chelating agent that destroys bacterial and fungal cell membrane and disrupts biofilm, may be an alternative to allow the associated antibiotic to act locally at a high and safe concentration. Methods: Fifty children with cancer and a port-a-cath were followed up: 26 received heparin (group 1) and 24 M-EDTA (group 2). A total of 762 serial prospective blood cultures were obtained, 387 from group 1 and 375 from group 2. Results: In group 1 (heparin), 19 blood cultures were positive, and infection incidence was 73.1% (19/26 ports). In group 2 (M-EDTA), 5 blood cultures were positive, and the incidence rate was 20.8% (5/24 ports). Conclusion: M-EDTA, compared with heparin, prevents and treats catheter infections, and is a promising alternative to decrease sepsis during chemotherapy. (Copyright © 2011 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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