| Autor: |
Shah DA; Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar-388 121, Gujarat, India. dimalgroup@yahoo.com, Patel NJ, Baldania SL, Chhalotiya UK, Bhatt KK |
| Jazyk: |
angličtina |
| Zdroj: |
Scientia pharmaceutica [Sci Pharm] 2011 Jan-Mar; Vol. 79 (1), pp. 113-22. Date of Electronic Publication: 2011 Jan 20. |
| DOI: |
10.3797/scipharm.1012-03 |
| Abstrakt: |
A simple, specific and stability indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of paracetamol and lornoxicam in tablet dosage form. A Brownlee C-18, 5 μm column having 250×4.6 mm i.d. in isocratic mode, with mobile phase containing 0.05 M potassium dihydrogen phosphate:methanol (40:60, v/v) was used. The flow rate was 1.0 ml/min and effluents were monitored at 266 nm. The retention times of paracetamol and lornoxicam were 2.7 min and 5.1 min, respectively. The linearity for paracetamol and lornoxicam were in the range of 5-200 μg/ml and 0.08-20 μg/ml, respectively. Paracetamol and lornoxicam stock solutions were subjected to acid and alkali hydrolysis, chemical oxidation and dry heat degradation. The proposed method was validated and successfully applied to the estimation of paracetamol and lornoxicam in combined tablet dosage form. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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