Vitamin C restores blood pressure and vasodilator response during mental stress in obese children.

Autor:	Fernandes PR; Universidade Federal da Paraíba, João Pessoa, PB, Brazil., Lira FA, Borba VV, Costa MJ, Trombeta IC, Santos Mdo S, Santos Ada C
Jazyk:	English; Portuguese; Spanish; Castilian
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2011 Jun; Vol. 96 (6), pp. 490-7. Date of Electronic Publication: 2011 May 06.
DOI:	10.1590/s0066-782x2011005000057
Abstrakt:	Background: Peripheral vasodilation response plays an important role in the pathophysiology of obesity and heart disease. Objective: To evaluate the chronic effect of vitamin C (VitC) supplementation on blood pressure and on vasodilation response to mental stress. Methods: In a double-blind, randomized and prospective study we evaluated obese children with 8 to 12 years in 2 similar groups: 1) supplemented with 500 mg VitC (n = 11) and 2) placebo (n = 10) for 45 days. Eight age-matched lean control children were also studied. We evaluated: mean blood pressure (MBP), heart rate (HR) and forearm blood flow by venous occlusion plethismography. Forearm vascular conductance (FVC) was calculated by: (forearm blood flow/PAM) X100. Results: On pre-intervention evaluations obese children showed higher MBP and lower FVC compared to lean control children. After intervention VitC diminished MBP at rest (81 ± 2 vs 75 ± 1 mmHg, p = 0.01), whereas placebo did not promote changes in MBP (p = 0.58). In addition, VitC promoted FVC increase at rest (3.40 ± 0.5 vs 5.09 ± 0.6 un, p = 0.04) and during the mental stress (3.92 ± 0.5 vs 6.68 ± 0.9 un, p = 0.03). Moreover, after VitC supplementation FVC levels were similar to the lean control children at rest (5.09 ± 0.6 vs 5.82 ± 0.4 un, p > 0.05) and during mental stress (6.68 ± 0.9 vs 7.35 ± 0.5 un, p > 0.05). Conclusion: VitC supplementation reduced the MBP and restored peripheral vasodilatation response during mental stress in obese children.
Databáze:	MEDLINE
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