| Abstrakt: |
Fundamental innovations in the study of the regulatory mechanisms of circulation in the past 20-30 years (evidence for the role of the endothelium in local hemodynamic control, the basic significance of the tissue link of the angiotensin mechanism (A-II) of not only as a vasoconstrictor, but also a trigger of a slow pressor component that remodels resistance bed arteries) have forced to revise the concept of the pathogenesis of hypertensive disease (HD) (essential hypertension) and confirmed its nosological isolation. The new refined and specified information on the pathogenesis of HD has shown to give doctors reliable landmarks to optimize drug therapy: 1) symptomatic for accelerated effective blood pressure lowering and 2) basic in order to eliminate endothelial dysfunction and to restore remodeled arteries and microcirculation. |
