| Autor: |
Marcoux FW; Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Mich 48105., Probert AW Jr, Weber ML |
| Jazyk: |
angličtina |
| Zdroj: |
Stroke [Stroke] 1990 Nov; Vol. 21 (11 Suppl), pp. III71-4. |
| Abstrakt: |
Calcium accumulation and neuronal injury were studied after hypoxia in cerebrocortical cell cultures in vitro. Neuronal injury was associated with a delayed calcium accumulation, which was greatest 5-7 hours after hypoxic exposure. Antiexcitotoxic treatments with tetrodotoxin and magnesium chloride or the selective N-methyl-D-aspartate antagonist (+/-)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid prevented hypoxic calcium accumulation and neuronal injury even when added 3 hours after hypoxia, during reoxygenation. Rescue of the neurons after hypoxia by blocking the delayed calcium accumulation in this cell culture preparation suggests a "therapeutic window" determined by calcium entry. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
