Use of Plerixafor with Granulocyte Colony-Stimulating Factor for Stem Cell Mobilization in a Pediatric Patient.
| Autor: | Bernardo VA; Valeria Alejandra Bernardo PharmD, Clinical Pharmacy Resident, St. Jude Children's Research Hospital, Memphis, TN vabernardo@hotmail.com., Ng JS; John Szechung Ng PharmD, Pediatric Clinical Pharmacist, Hematology, Oncology, Stem Cell Transplant, Wolfson Children's Hospital/Baptist Medical Center, Jacksonville, FL., Joyce MJ; Michael John Joyce MD PhD, Program Director of Pediatric Blood and Marrow Transplantation, Division of Hematology, Oncology, Nemours Children's Clinic, Jacksonville. |
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| Jazyk: | angličtina |
| Zdroj: | The Annals of pharmacotherapy [Ann Pharmacother] 2011 Feb; Vol. 45 (2), pp. e12. |
| DOI: | 10.1345/aph.1P564 |
| Abstrakt: | Objective: To present a case where plerixafor was successfully used in combination with granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem cells in a pediatric patient. Case Summary: An 11-year-old boy with recurrent anaplastic large-cell lymphoma failed to yield an adequate number of CD34+ cells with G-CSF for mobilization. After a single subcutaneous dose of plerixafor 240 μg/kg was administered in addition to filgrastim, sufficient CD34+ cells were harvested for transplantation. A local injection site reaction was the only adverse reaction reported. Discussion: Several studies in adults have shown plerixafor to be effective for the mobilization of hematopoietic stem cells when used in combination with G-CSF in adults with non-Hodgkin's lymphoma and multiple myeloma who failed to mobilize sufficient CD34+ cells with G-CSF alone. There is limited information regarding the safety and efficacy of plerixafor in pediatric patients. Conclusions: Plerixafor was effective in increasing the number of hematopoietic stem cells in the peripheral blood of an 11-year-old patient; studies are needed to evaluate the safety and effectiveness of plerixafor in pediatric patients. (© 2011 SAGE Publications.) |
| Databáze: | MEDLINE |
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