The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease.
| Autor: | Gatenby VK; University of Leeds Multidisciplinary Cardiovascular Research Centre, Leeds, UK., Kearney MT |
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| Jazyk: | angličtina |
| Zdroj: | Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2010 Dec; Vol. 14 (12), pp. 1333-42. |
| DOI: | 10.1517/14728222.2010.528930 |
| Abstrakt: | Importance of the Field: The insulin-resistant conditions of type 2 diabetes mellitus (T2DM) and obesity are a major cause of cardiovascular disease on a global scale. These disorders are not only a cause of ill health but are a huge financial drain on healthcare systems. T2DM leads to an increased risk of cardiovascular mortality equivalent to over 10 years of ageing while obesity independent of T2DM also leads to a substantially increased risk of acute myocardial infarction. Recent trials of therapeutic agents and approaches to preventing the cardiovascular complications of type 2 diabetes have been disappointing. Areas Covered in This Review: The role of insulin resistance in the endothelium in the regulation of the anti-atherosclerotic signalling molecule NO and a potential important role for IGF-1 in vascular NO production. What the Reader Will Gain: A comprehensive understanding of how insulin and IGF-1 regulate vascular function and the effect of type 2 diabetes on these pathways. Take Home Message: The roles of insulin and IGF-1 in vascular function are complex and intimately related. Nevertheless IGF-1 signalling in the arterial wall has the potential to be manipulated to protect the vasculature against the development of atherosclerosis and its devastating complications. |
| Databáze: | MEDLINE |
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