| Autor: |
Pogorelov AG, Pogorelova VN, Pogorelova MA |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2010 Sep-Oct; Vol. 55 (5), pp. 875-9. |
| Abstrakt: |
Electron probe microanalysis was applied to determine cytoplasmic elemental (K, Na, Cl) concentrations in cardiac cells of the rat (Wistar). Potassium, sodium and chlorine contents were measured in papillary muscle myocytes of the rat heart perfused by the Langendorff's procedure. Ischemic depletion was created by perfusion with deeply deoxygenated Tirode's solution in the absence of glucose. It was found that the initial phase of acute ischemia is characterized by the potassium deficiency and the accumulation of sodium and chlorine in cardiac myocytes. It should be noted that changes in the total charge of the main intracellular cations (K+, Na+) do not compensate for the increased chlorine concentration. This result can be accounted for by the appearance of ionic (K+ and Cl-) transport coupled with the removal of lactate anions produced in cardiomyocytes during anaerobic glycolysis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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