| Autor: |
Furth PS; Dept of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Rosenberger J, Marcotte PA, Robinson CH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of enzyme inhibition [J Enzyme Inhib] 1990; Vol. 4 (2), pp. 131-5. |
| DOI: |
10.3109/14756369009040734 |
| Abstrakt: |
2,2-Dimethyl-4-hydroxy-4-androstene-3,17-dione (4) has been synthesized and has been shown to be a powerful competitive inhibitor of aromatase (Ki = 11.4 nM). However, compound 4 does not cause time-dependent loss of enzyme activity, in contrast to the unmethylated parent compound, 4-OHA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
