[The effectiveness of intravitreal administration of bevacizumab for choroidal neovascularization in retinal angioid streaks].

Autor:	Noda E; Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon-shi, Ehime-ken 791-0295, Japan., Joko T, Tasaka Y, Ohashi Y
Jazyk:	japonština
Zdroj:	Nippon Ganka Gakkai zasshi [Nippon Ganka Gakkai Zasshi] 2010 Jul; Vol. 114 (7), pp. 612-20.
Abstrakt:	Purpose: To investigate the effectiveness of intravitreal administration of bevacizumab (IVB) for choroidal neovascularization (CNV) in retinal angioid streaks (AS). Subjects and Methods: Five eyes of four subjects with CNV in AS were observed for an average followup period of 12 months. The average greatest linear diameter (GLD) of the AS was 4315 microm before treatment. IVB (1.0 mg or 1.25 mg) was performed a total of two times at eight week intervals, and additional bevacizumab was administered whenever exudative changes occurred. Results: Visual acuity improved in one eye (20%), was maintained in two eyes (40%), and worsened in two eyes (40%). Recurrence of CNV was observed in two eyes (40%). Before treatment, the GLD was 2439, 2844, and 3654 microm in the three eyes in which visual acuity was maintained, and 5803 and 6837 microm in the two eyes with worsened visual acuity. Recurrence of CNV was observed in the two eyes with worsened visual acuity. Conclusion: Short-term CNV fibrosis and maintenance of visual acuity were achieved with IVB in cases in which the GLD was less than 3500 microm.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu