| Autor: |
Genelhu VA; Laboratório de Fisiopatologia Clínica e Experimental (CLINEX), Clínica de Hipertensão, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Francischetti EA, Duarte SF, Celoria BM, Oliveira RC, Cabello PH, Pimentel MM |
| Jazyk: |
angličtina |
| Zdroj: |
Genetics and molecular research : GMR [Genet Mol Res] 2010; Vol. 9 (3), pp. 1392-7. |
| DOI: |
10.4238/vol9-3gmr819 |
| Abstrakt: |
We determined whether ADRbeta3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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