Synthesis and molecular modeling studies of 3-chloro-4-substituted-1-(8-hydroxy-quinolin-5-yl)-azetidin-2-ones as novel anti-filarial agents.

Autor: Chhajed SS; Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Dhamangaon, Dist-Nasik, MS, India. santosh_chhajed@rediffmail.com, Manisha P, Bastikar VA, Animeshchandra H, Ingle VN, Upasani CD, Wazalwar SS
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jun 15; Vol. 20 (12), pp. 3640-4. Date of Electronic Publication: 2010 May 17.
DOI: 10.1016/j.bmcl.2010.04.106
Abstrakt: A series of 3-chloro-4-substituted-1-(8-hydroxy-quinolin-5-yl)-azetidin-2-ones were synthesized and evaluated for their in vitro anti-filarial activity. To pre-assess the anti-filarial behavior of synthesized compounds (V(a-f)) on a structural basis, automated docking studies were carried out with Molecular Design Suite (MDS v 3.5) into the active site of glutathione-S-transferase (GST) enzyme; scoring functions of these compounds at the active site of the GST enzyme were used for correlation with observed activity. Compounds V(e) and V(f) have shown good affinity for receptor GST, as well as in vitro anti-filarial potency.
(Copyright 2010 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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